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Carraro-Doonan-Falcaro-PhaseDiagram.pdf (1.1 MB)
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Phase Dependent Encapsulation and Release Profile of ZIF-Based Biocomposites

preprint
submitted on 28.10.2019 and posted on 06.11.2019 by Francesco Carraro, Miriam Velasquez, Efwita Astria, Weibin Liang, liam Twight, chiara parise, meng ge, Zhehao Huang, Raffaele Ricco, Xiaodong Zou, laura villanova, C. Oliver Kappe, Christian Doonan, paolo falcaro
Here we systematically varied the composition of the relative amounts of ligand (2-methylimidazole), metal precursor (Zn(OAc)2∙2H2O, and protein to prepare a series of protein@ZIF biocomposites. The effect of post synthetic treatments (i.e. washes with water or water/ethanol) was investigated. The XRD data of the examined samples were used to construct ternary diagrams. Five different phases were identified. The encapsulation efficiency (of bovine serum albumin and insulin) were phase dependent.

Funding

POPCRYSTAL 771834

FETOPEN-1-2016-2017 801464

Metal-organic frameworks at the biointerface

Australian Research Council

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TU Graz Lead Project LP-O3

CVU 419210

MNEMONIC 748649

KAW 2016.0072

Swedish Research Council 2017-0432

History

Email Address of Submitting Author

paolo.falcaro@tugraz.at

Institution

Graz University of Technology

Country

Austria

ORCID For Submitting Author

0000-0001-5935-0409

Declaration of Conflict of Interest

No conflict of interest

Version Notes

Corresponding authors: Paolo Falcaro and Christian Doonan

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