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Patient-Derived Microvesicles/AIE Luminogen Hybrid System for Personalized Sonodynamic Cancer Therapy in Patient-Derived Xenograft Models

preprint
submitted on 04.07.2020 and posted on 06.07.2020 by Daoming Zhu, Zheng Zheng, Meng Suo, zeming liu, Yanhong Duo, Ben Zhong Tang

Sonodynamic therapy (SDT), as an efficient way of tumor treatment, has the advantages of deep tumor penetration and high therapeutic efficacy. However, developing efficient sonosensitizers are still challenging. AIEgen-based SDT has never been reported and it is urgent to develop novel AIEgen-active sonosensitizers. Furthermore, the AIEgen-based theranostic system is promisingly needed to be proved on PDX models to be closer to the clinic. Herein, we constructed the first AIEgen based SDT system and found that DCPy has advantages over traditional sonosensitizers in SDT. Then, a patient-derived MVs/AIEgen hybrid system prepared by electroporation was used for personalized SDT in bladder cancer patient-derived xenograft (PDX) models. Impressively, AMVs displayed the superior tumor targeting ability and efficient personalized SDT therapy on PDX models, both of which were much more improved compared with PLGA/AIEgens nanoparticles and cell line-derived micro vesicles. This work presented the first example of an AIEgen-based hybrid system as sonosensitizer for SDT and provides new ideas for both the design of AIE-active sonosensitizers and the SDT treatment of cancers, further expanding the potential clinical application of AIEgens in the future.

Funding

the State Key Research Development Program of China (Grant No. 2019YFB2203503), National Natural Science Foundation of China (Grant No. 61875138, 61435010, and 61961136001), the Research Grants of Council of Hong Kong (N-HKUST609/19, A-HKUST605/16 and C6009-17G) and the Innovation of Technology Commission (ITC-CNERC14SC01).

History

Email Address of Submitting Author

duoduo7753@126.com

Institution

Shenzhen People’s Hospital

Country

China

ORCID For Submitting Author

0000-0002-7897-795X

Declaration of Conflict of Interest

The authors declare no conflict of interest.

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