These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
revised on 02.11.2019 and posted on 07.11.2019by Jie Wu, Zengwei Wang, Xiao-Yue Chen, Yichen Wu, Daoming Wang, Qian Peng, Peng Wang
Herein, we conceptualized
a transient mediator approach that has the capability of para-selective C–H functionalization of monosubstituted aromatics.
This approach is enabled by in situ generation of a versatile sulfonium salt via highly
electrophilic phenoxathiine or thianthrene dication
intermediate which can be readily generated from its sulfoxide with
trifluoromethanesulfonic anhydride. Preliminary mechanistic study implied
that the remarkable para selectivity might
be related to the incredible electrophilicity of thianthrene dication
intermediate. The versatility of this approach was demonstrated via para-borylation of various monosubstituted
simple aromatics combining the sulfonium salt formation with further photocatalyzed