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Palladium(II)-Catalyzed γ-Selective Hydroarylation of Alkenyl Carbonyl Compounds with Arylboronic Acids

preprint
submitted on 17.04.2018 and posted on 17.04.2018 by Rei Matsuura, Tanner Jankins, Kin Yang, Gary Gallego, Shouliang Yang, Mingying He, Fen Wang, Rohan Marsters, Indrawan McAlpine, Keary Engle
A catalytic γ-selective syn-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed using a substrate directivity approach with a palladium(II) catalyst. This method tolerates a wide range of functionalized (hetero)arylboronic acids and a variety of substitution patterns on the alkene.

Funding

1R35GM125052

History

Email Address of Submitting Author

keary@scripps.edu

Email Address(es) for Other Author(s)

matsuura@scripps.edu jankinst@scripps.edu kin@uchicago.edu gary.gallego@pfizer.com shouliang.yang@pfizer.com mingying.he@pfizer.com fen.wang@pfizer.com rmarsters2019@hightechhigh.org indrawan.mcalpine@pfizer.com

Institution

The Scripps Research Institute

Country

USA

ORCID For Submitting Author

0000-0003-2767-6556

Declaration of Conflict of Interest

No conflict of interest to declare.

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