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Palladium-Catalyzed Denitrative Mizoroki–Heck Reaction

preprint
submitted on 16.03.2020 and posted on 17.03.2020 by Toshimasa Okita, Kitty K. Asahara, Kei Muto, Junichiro Yamaguchi

We have developed a Mizoroki–Heck reaction of nitroarenes with alkenes under palladium catalysis. The use of a Pd/BrettPhos catalyst promoted the alkenylation, whereas other catalysts led to a decrease in the product yield. In addition to nitroarenes, nitroheteroarenes were also applicable to the present reaction. Combination of a nucleophilic aromatic substitution (SNAr) with the denitrative alkenylation produced a multi-functionalized arene in a one-pot operation.

History

Email Address of Submitting Author

junyamaguchi@waseda.jp

Institution

Waseda University

Country

Japan

ORCID For Submitting Author

0000-0002-3896-5882

Declaration of Conflict of Interest

No competing financial interests have been declared.

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