These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
RXiv sub.pdf (397.57 kB)

Oxidase Catalysis via an Aerobically Generated Dess-Martin Periodinane Analogue

submitted on 17.04.2018, 16:23 and posted on 18.04.2018, 13:54 by Asim Maity, Sung-Min Hyun, Alan Wortman, David Powers

Hypervalent iodine(V) reagents, such as Dess-Martin periodinane (DMP) and 2-iodoxybenzoic acid (IBX), are broadly useful oxidants in chemical synthesis. Development of strategies to access these reagents from O2 would immediately enable use of O2 as a terminal oxidant in a broad array of substrate oxidation reactions. Recently we disclosed the aerobic synthesis of I(III) reagents by intercepting reactive oxidants generated during aldehyde autoxidation. Here, we couple aerobic oxidation of iodobenzenes with disproportionation of the initially generated I(III) compounds to generate I(V) reagents. The aerobically generated I(V) reagents exhibit substrate oxidation chemistry analogous to that of DMP. Further, the developed aerobic generation of I(V) has enabled the first application of I(V) intermediates in aerobic oxidation catalysis.


The Welch Foundation (A-1907)


Email Address of Submitting Author


Texas A&M University



ORCID For Submitting Author


Declaration of Conflict of Interest

There are no conflicts of interest.


Read the published paper

in Angewandte Chemie International Edition