These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
5 files

Ortho-Phenylene-Based Macrocyclic Hydrocarbons Assembled Using Olefin Metathesis

submitted on 24.04.2020, 18:35 and posted on 27.04.2020, 09:21 by Viraj kirinda, Briana Schrage, Christopher Ziegler, Scott Hartley
While many foldamer systems reliably fold into well-defined secondary structures, higher order structure remains a challenge. A simple strategy for the organization of folded subunits in space is to link them together within a macrocycle. Previous work has shown that o-phenylenes can be co-assembled with rod-shaped linkers into twisted macrocycles, showing an interesting synergy between folding and thermodynamically controlled macrocyclization. In these systems the foldamer units were largely decoupled from each other both conformationally and electronically. Here, we show that hydrocarbon macrocycles, with very short ethenylene linkers, can be assembled from o-phenylenes using olefin metathesis. Characterization by NMR spectroscopy, X-ray crystallography, and ab initio calculations shows that the products are approximately triangular [3+3] macrocycles with helical o-phenylene corners in a heterochiral configuration. Their photophysics are dominated by the 4,4′-diphenylstilbene moieties, the longest conjugated segments, with further conjugation broken by the twisting of the o-phenylenes.


National Science Foundation CHE-1608213

National Science Foundation CHE-1904236


Email Address of Submitting Author


Miami University



ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest