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Manuscript Dr. Narendra 14 July 2020.pdf (560.18 kB)

Organophotoredox-Catalyzed Direct C-H Functionalization of “Drug Prejudice” at Room Temperature

preprint
revised on 25.09.2020 and posted on 28.09.2020 by Narendra Chaubey, Anant Kapdi, Biswanath Maity

Organophotocatalytic C─H bond functionalization has attracted lot of attention in the past several years due to the possibility of catalysing reactions in a metal-free environment. Continuing on these lines, we repot herein an organophotoredox catalyzed C─H functionalization of imidazo[1,2-a]pyridines and related heterocycles with malonates under mild conditions providing excellent yields of the products at room temperature. Although, C─3 functionalization of imidazo[1,2-a]pyridines are known, this is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including Zolpidem, a sedative-hypnotic medicine.

Funding

Indian Council of Medical Research (45/15/2019-BIO/BMS)

History

Email Address of Submitting Author

narendra581981@gmail.com

Institution

Institute of Chemical Technology, Matunga, Mumbai-400019

Country

India

ORCID For Submitting Author

https://orcid.org/0000-0001-6911-9243

Declaration of Conflict of Interest

There are no conflicts to declare

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