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Optoregulated Drug Release from an Engineered Living Hydrogel
preprintsubmitted on 13.09.2018, 21:52 and posted on 14.09.2018, 16:51 by Shrikrishnan Sankaran, Judith Becker, Christoph Wittmann, Aránzazu del Campo
A living hydrogel has been developed with metabolically and optogenetically engineered E. coli encapsulated within an agarose-based hydrogel matrix to produce and release deoxyviolacein in response to blue light irradiation. Localized, tunable and prolonged drug release have been demonstrated.