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Optical Control of Small Molecule-Induced Protein Degradation

preprint
submitted on 02.06.2019 and posted on 03.06.2019 by Yuta Naro, Kristie Darrah, Alexander Deiters

As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discreet spatiotemporal control over its activity, we have developed a broadly applicable approach for the optical control of small molecule-induced protein degradation. Installation of photolabile caging groups onto ligands recruiting Von Hippel-Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases enabled optical control over protein degradation.

Funding

NSF CHE-1404836

History

Email Address of Submitting Author

alexdeiters@gmail.com

Institution

University of Pittsburgh

Country

USA

ORCID For Submitting Author

0000-0003-0234-9209

Declaration of Conflict of Interest

None.

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in Journal of the American Chemical Society

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