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On the Reactivity of mRNA Caps: C-H Oxidative Addition of 7-Methylguanosine to Pt(0)

preprint
submitted on 17.05.2019, 15:32 and posted on 20.05.2019, 17:29 by Maria Ines Leitao, Carmen Gonzalez, Zuzanna Filipiak, Ana Petronilho

7-methylguanosine, the so-called mRNA cap 0 bears a very labile C8-H bond, due to the formation of an ylide/N-heterocyclic carbene, upon proton loss. The reaction of 7-methylguanosine with Pt(PPh3)4, via C-H oxidative addition, yields a hydrido–PtII carbene complex and this reactivity can be extrapolated to 7,9-dimethylguanine.

History

Email Address of Submitting Author

ana.petronilho@itqb.unl.pt

Institution

Instituto de Tecnologia Química e Biológica Antonio Xavier

Country

Portugal

ORCID For Submitting Author

0000-0002-3296-1522

Declaration of Conflict of Interest

No Conflict of Interest

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