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Nucleophilic Substitution Reactions of Cyclic Thiosulfinates Are Accelerated by Hyperconjugative Interactions
preprintsubmitted on 25.04.2019, 02:13 and posted on 25.04.2019, 20:32 by Daniel Donnelly, Jeffrey Agar, Steven Lopez
Strain energy has been shown to promote the nucleophilic substitution reactions of cyclic disulfides, the reactivities of cyclic thiosulfinate nucleophilic substitution is unexplored. We used density functional theory calculations [M06-2X/6-311++G(d,p)] to determine the activation and reaction free energies for the reactions of 3—10-membered cyclic thiosulfinates and cyclic disulfides with methyl thiolate.
Read the published paper
in Chemical Science