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Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds

preprint
submitted on 10.12.2019, 12:22 and posted on 19.12.2019, 20:31 by Matthias Grill, Melanie Patt, Alex Odermatt
Anabolic androgenic steroids (AAS) are frequently used either clinically, by athletes, or for body shaping due to their muscle building and performance enhancing properties. AAS misuse is associated with cardiovascular diseases, mood changes and endocrine issues. Despite the recognition of the severe adverse effects of AAS misuse, the underlying molecular mechanisms are insufficiently understood. Selective androgen receptor modulators (SARMs) are supposed to diminish the adverse androgenic AAS effects while maximizing anabolic effects. In order to obtain androgen receptor modulating compounds of high purity for mechanistic in vitro investigations, this study summarizes protocols of optimized chemical synthesis for five AAS and two SARMs.

Funding

Swiss Centre for Applied Human Toxicology

History

Email Address of Submitting Author

alex.odermatt@unibas.ch

Institution

University of Basel

Country

Switzerland

ORCID For Submitting Author

0000-0002-6820-2712

Declaration of Conflict of Interest

Matthias Grill was an employee of Lipomed AG, the other authors have nothing to declare.

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