These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
3 files

Nitrile Reduction Reverses the Micropollutant Uptake Selectivity of a Tetrafluoroterephthalonitrile-β-Cyclodextrin Polymer

submitted on 18.02.2019, 19:21 and posted on 19.02.2019, 17:13 by Max Justin Klemes, Yuhan Ling, Casey Ching, congyue wu, Leilei Xiao, Damian E Helbling, William Dichtel
A post-polymerization reduction of nitrile groups to primary amines reverses the selectivity of a crosslinked cyclodextrin polymer network. The as-polymerized material had previously been shown to have a high affinity for cationic organic micropollutants. The reduced polymer has a high affinity for anionic pollutants, including a broad range of per- and polyfluorinated alkyl substances (PFASs).


NSF CHE-1413862

SERDP ER18-1026

NSF CHE-1541820

NSF CHE-1048773

NSF ECCS-1542205


Email Address of Submitting Author


Northwestern University



ORCID For Submitting Author


Declaration of Conflict of Interest

Northwestern University and Cornell University have filed a patent application based on the results described in this article. D.E.H. and W.R.D. serve on the scientific advisory board and own equity and/or stock options in CycloPure, Inc., which is commercializing related cyclodextrin polymers.