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submitted on 07.02.2020 and posted on 07.02.2020by Xiao-Xu Wang, Xi Lu, Shi-Jiang He, Yao Fu
report a three-component olefin reductive dicarbofunctionalization for
constructing densely functionalized alkylborates, specifically,
nickel-catalyzed reductive dialkylation and alkylarylation of vinyl boronates
with a variety of alkyl bromides and aryl iodides. This reaction exhibits good
coupling efficiency and excellent functional group compatibility, providing
convenient access to the late-stage modification of complex natural products
and drug molecules. Combined with versatile alkylborate transformations, this
reaction could also find applications in the modular and convergent synthesis
of complex, densely functionalized compounds.
the National Natural Science Foundation of China (Grants 21732006, 21702200, 51821006, and 51961135104), the National Key R&D Program of China (Grant 2017YFA0303502), and the Strategic Priority Research Program of CAS (Grant XDB20000000)