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Nickel-Catalyzed Three-Component Olefin Reductive Dicarbofunctionalization to Access Highly Functionalized Alkylborates

submitted on 07.02.2020, 06:12 and posted on 07.02.2020, 12:53 by Xiao-Xu Wang, Xi Lu, Shi-Jiang He, Yao Fu
We report a three-component olefin reductive dicarbofunctionalization for constructing densely functionalized alkylborates, specifically, nickel-catalyzed reductive dialkylation and alkylarylation of vinyl boronates with a variety of alkyl bromides and aryl iodides. This reaction exhibits good coupling efficiency and excellent functional group compatibility, providing convenient access to the late-stage modification of complex natural products and drug molecules. Combined with versatile alkylborate transformations, this reaction could also find applications in the modular and convergent synthesis of complex, densely functionalized compounds.


the National Natural Science Foundation of China (Grants 21732006, 21702200, 51821006, and 51961135104), the National Key R&D Program of China (Grant 2017YFA0303502), and the Strategic Priority Research Program of CAS (Grant XDB20000000)


Email Address of Submitting Author


University of Science and Technology of China



ORCID For Submitting Author


Declaration of Conflict of Interest

There is no conflict of interest to report.