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Nickel-Catalyzed Thiolation of Aryl Nitriles

preprint
submitted on 09.04.2021, 12:05 and posted on 09.04.2021, 13:28 by Tristan Delcaillau, Bill Morandi
A nickel-catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2 Bis(dicyclohexylphosphino)ethane) as well as the base KOtBu (potassium tert-butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C–C bond activation and a C–S bond formation. Furthermore, this reaction shows a high functional-group tolerance and enables the late-stage functionalization of important molecules.

Funding

Swiss National Science Foundation

Federal Department of Economic Affairs Education and Research

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ETH Zurich

History

Email Address of Submitting Author

morandib@ethz.ch

Institution

ETH Zurich

Country

Switzerland

ORCID For Submitting Author

0000-0003-3968-1424

Declaration of Conflict of Interest

N/A

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