ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Nickel-Catalyzed Hydroalkylation and Hydroalkenylation of 1,3-Dienes with Hydrazones

preprint
submitted on 10.06.2019 and posted on 12.06.2019 by Lei Cheng, Ming-Ming Li, Biao Wang, LIJUN XIAO, JIANHUA XIE, QILIN ZHOU
In this article, we report a protocol for nickel catalyzed hydroalkylation of dienes with hydrazones, which serve as equivalents of unstabilized carbon nucleophiles. In addition, we developed a protocol for hydroalkenylation of dienes with α,β unsaturated hydrazones, providing a new method for the synthesis of 1,4 dienes. These hydroalkylation and hydroalkenylation reactions feature mild conditions and a wide substrate scope, and the utility of the reaction products is demonstrated by the preparation of an activator of soluble guanylate cyclase.

History

Email Address of Submitting Author

2120150691@mail.nankai.edu.cn

Institution

Nankai University

Country

China

ORCID For Submitting Author

0000-0001-5247-7431

Declaration of Conflict of Interest

The authors declare no competing financial interest.

Exports

Logo branding

Exports