These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
submitted on 10.06.2019 and posted on 12.06.2019by Lei Cheng, Ming-Ming Li, Biao Wang, LIJUN XIAO, JIANHUA XIE, QILIN ZHOU
In this article, we report a protocol for nickel catalyzed hydroalkylation of dienes with hydrazones, which serve as equivalents of unstabilized carbon nucleophiles. In addition, we developed a protocol for hydroalkenylation of dienes with α,β unsaturated hydrazones, providing a new method for the synthesis of 1,4 dienes. These hydroalkylation and hydroalkenylation reactions feature mild conditions and a wide substrate scope, and the utility of the reaction products is demonstrated by the preparation of an activator of soluble guanylate cyclase.