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Nickel-Catalyzed Hydroalkylation and Hydroalkenylation of 1,3-Dienes with Hydrazones
preprintsubmitted on 10.06.2019, 06:42 and posted on 12.06.2019, 12:09 by Lei Cheng, Ming-Ming Li, Biao Wang, LIJUN XIAO, JIANHUA XIE, QILIN ZHOU
In this article, we report a protocol for nickel catalyzed hydroalkylation of dienes with hydrazones, which serve as equivalents of unstabilized carbon nucleophiles. In addition, we developed a protocol for hydroalkenylation of dienes with α,β unsaturated hydrazones, providing a new method for the synthesis of 1,4 dienes. These hydroalkylation and hydroalkenylation reactions feature mild conditions and a wide substrate scope, and the utility of the reaction products is demonstrated by the preparation of an activator of soluble guanylate cyclase.
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in Chemical Science