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Nickel-Catalyzed Cross Coupling of Umpolung Carbonyls and Alkyl Halides

preprint
submitted on 02.02.2019 and posted on 04.02.2019 by Dianhu Zhu, Leiyang Lv, Zihang Qiu, Chao-Jun Li
An effective nickel-catalyzed cross coupling of umpolung carbonyls and alkyl halides was developed. Contrary to classical alkylation techniques, this reaction utilizes umpolung carbonyls as the environmentally benign alkyl nucleophiles, providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.

History

Email Address of Submitting Author

dianhuzhu@gmail.com

Institution

McGill University

Country

Canada

ORCID For Submitting Author

0000-0001-5415-9648

Declaration of Conflict of Interest

The authors declare no competing financial interests.

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