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Nickel-Catalyzed Benzylic Alkynylation: Migratory Hydroalkynylation and Enantioselective Hydroalkynylation of Olefins with Bromoalkynes

preprint
submitted on 01.02.2021, 19:50 and posted on 02.02.2021, 11:13 by Xiaoli Jiang, Bo Han, Yuhang Xue, Mei Duan, Zhuofan Gui, You Wang, Shaolin Zhu
A nickel-hydride catalyzed reductive migratory hydroalkynylation of olefins with bromoalkynes that delivers the corresponding benzylic alkynylation products in high yield and with excellent regioselectivity has been developed. Catalytic enantioselective hydroalkynylation of styrenes has been realized using a simple chiral PyrOx ligand. The obtained enantioenriched benzylic alkynes are versatile synthetic intermediates and can be readily transformed into synthetically useful chiral synthons

Funding

National natural Science Foudation of China 21822105

National natural Science Foudation of China 21772087

National natural Science Foudation of Jiangsu Province (BK20190281, BK20201245)

History

Email Address of Submitting Author

shaolinzhu@nju.edu.cn

Institution

Nanjing University

Country

China

ORCID For Submitting Author

0000-0003-1516-6081

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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