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Ni(0)-Catalyzed α-Allylic Alkylation of Regular Ketones with 1,3-Dienes under pH and Redox-neutral Conditions

preprint
revised on 15.04.2019, 08:24 and posted on 15.04.2019, 16:21 by Tiantian Chen, Yang Yang, Liyu Xie, Haijian Yang, Guangbin Dong, Dong Xing

We report a Ni(0)-catalyzed cross coupling reaction between simple ketones and 1,3-dienes. A variety of a-allylic alkylation products were formed in an 1,2-addition manner with excellent regioselectivity. Water was found to significantly accelerate this transformation. A HO-Ni-H species generated from oxidative addition of Ni(0) to H2O is proposed to play a “dual role” in activating both the ketone and the diene substrate.

History

Email Address of Submitting Author

dxing@sat.ecnu.edu.cn

Institution

East China Normal University & University of Chicago

Country

China

ORCID For Submitting Author

0000-0003-3718-4539

Declaration of Conflict of Interest

no conflict of interest

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