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NiH-Catalyzed Asymmetric Hydroarylation of N-Acyl Enamines: Practical Access to Chiral Benzylamines

preprint
submitted on 13.10.2020 and posted on 14.10.2020 by Yuli He, Huayue Song, Shaolin Zhu
The enantio- and regioselective reductive hydroarylation of N-acyl enamines has been achieved with a NiH catalyst and a chiral bis-imidazoline ligand. A broad range of structurally diverse, enantioenriched benzylamines, a moiety found in many pharmacologically active molecules, have been synthesized efficiently under mild, operationally simple reaction conditions.

Funding

National Natural Science Foundation of China 21822105

National Natural Science Foundation of China 21772087

National Natural Science Foundation of China 22001118

History

Email Address of Submitting Author

shaolinzhu@nju.edu.cn

Institution

NanjingUniversity

Country

China

ORCID For Submitting Author

0000-0003-1516-6081

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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