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Ni-Catalyzed Conversion of Enol Triflates to Alkenyl Halides

preprint
submitted on 10.07.2019 and posted on 15.07.2019 by Julie Hofstra, Kelsey Poremba, Alex M. Shimazono, Sarah Reisman
A Ni-catalyzed halogenation of alkenyl triflates was developed that enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench stable Ni(OAc)2•4H2O as a pre-catalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either cod or DMAP as a supporting ligand.

Funding

National Science Foundation DGE-1144469

NIGMS R35GM118191-01

History

Email Address of Submitting Author

reisman@caltech.edu

Institution

California Institute of Technology

Country

United States

ORCID For Submitting Author

0000-0001-8244-9300

Declaration of Conflict of Interest

none

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Read the published paper

in Angewandte Chemie

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