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Ni-Catalyzed Conversion of Enol Triflates to Alkenyl Halides
preprintsubmitted on 10.07.2019, 17:52 and posted on 15.07.2019, 15:58 by Julie Hofstra, Kelsey Poremba, Alex M. Shimazono, Sarah Reisman
A Ni-catalyzed halogenation of alkenyl triflates was developed that enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench stable Ni(OAc)2•4H2O as a pre-catalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either cod or DMAP as a supporting ligand.
Read the published paper
in Angewandte Chemie