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New Insights into the Reactivity of 2-Halo-Glycals. Synthesis of Novel Iodinated Oand S-Glycosides

preprint
submitted on 29.06.2020 and posted on 01.07.2020 by Agustín Rojas, Leticia Lafuente, Virginia Vetere, Agustin Ponzinibbio

This is the first report on the Ferrier rearrangement of 2-halo-glycals with S-nucleophiles. We present herein the selective synthesis of new 2-iodo-2,3-unsaturated O- and S-glycosides. We obtained in good yields and high anomeric selectivity a-glycosydes. As a particular behaviour, we also describe heteroaromatic thio sugar derivatives were the C3 addition was performed in an alternative mechanism. A complete structure and conformation analysis by NMR was also presented.

History

Email Address of Submitting Author

ponzi1975@gmail.com

Institution

UNLP

Country

Argentina

ORCID For Submitting Author

0000-0003-4610-916X

Declaration of Conflict of Interest

No conflict of interest

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