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Natural Flavonoids as Superior Reagents for Separation of Clinically Important Zr Radionuclides
preprintsubmitted on 24.10.2019, 17:31 and posted on 28.10.2019, 21:16 by Kalpita Ghosh, Nabanita Naskar, Dibyasree Choudhury, Susanta Lahiri
This paper exploits the affinity of bio-flavonoid hesperidin, isolated from orangepeel, towards the separation of clinically important 88Zr radionuclide from high energy proton bombarded yttrium target. The extraction of Zr with hesperidin was studied by solid-liquid extraction (SLX) technique over a wide pH range. The advantage of hesperidin is that it acts as separating agent as well as free-radical scavenging agent upon injection of the radionuclidehesperidin complex in-vivo. The stability of isolated hesperidin under strong radiation field was also studied. The selectivity of the bio-flavonoid towards 88Zr was maximum at pH=4 where in >78% Zr was extracted with <1% contamination from bulk yttrium target.