ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Nanohoop Rotaxane Design to Enhance Selectivity of Reaction Based Probes: A Proof of Principle Study

preprint
submitted on 16.09.2020 and posted on 16.09.2020 by Claire Otteson, Carolyn Levinn, Jeff Van Raden, Michael Pluth, Ramesh Jasti

A novel fluorescent probe design based on the interlocking of a reactive thread in a rigid nanohoop fluorophore is reported. This rotaxane design leads to size-selective sensing of thiolates in organic solution. More broadly, the work suggests the promise of mechanical interlocking to enhance the selectivity of reaction-based probes.

Funding

CHE-1808791

Chemical Tools for Delivery and Detection of Biological Hydrogen Sulfide

National Institute of General Medical Sciences

Find out more...

DGE-1309047

History

Email Address of Submitting Author

rjasti@uoregon.edu

Institution

University of Oregon

Country

USA

ORCID For Submitting Author

0000-0002-8606-6339

Declaration of Conflict of Interest

There are no conflicts to declare.

Exports

Logo branding

Exports