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NMR for Mixture Analysis: Concentration Ordered Spectroscopy
preprintsubmitted on 22.02.2021, 03:15 and posted on 23.02.2021, 05:25 by Bin Yuan, Zhiming Zhou, Bin Jiang, Ghulam Mustafa Kamal, Xu Zhang, Conggang Li, Xin Zhou, Maili Liu
A novel approach, concentration ordered NMR spectroscopy (CORDY), is being proposed based on the principle that the ratio of NMR peak area to its associated number of spins is proportional to the concentration of the assigned compound.CORDY generates a pseudo 2-dimensional NMR spectrum with chemical shifts in one axis and concentrations in the other, resulting both in separation and quantitation of components in complex samples. The method was validated by applying on three samples. It was demonstrated that CORDY could successfully provide separation up to two orders of magnitude in concentration dimension, for the samples used in current study.