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submitted on 29.09.2020 and posted on 30.09.2020by Lei Chen, Shiyi Jin, Jian Gao, Tongtong Liu, Yuebo Shao, Jie Feng, Kangyi Wang, Tao Lu, Ding Du
An N-heterocyclic carbene and
magnesium co-catalyzed three-component alkylacylation of alkenes with cycloketone
oxime esters and aldehydes was presented. This method displayed good scope
generality, providing a transition metal and photo-redox free pathway to access
various multi-functionalized aliphatic keto-nitrile structures under mild
reaction conditions. Moreover, this strategy is supposed to follow a radical
relay mechanism via a single electron transfer (SET) event of Mg/oxime
ester/Breslow intermediate ternary electron donating acceptor (EDA) complex.