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N-Heterocyclic Carbene/Magnesium Co-catalyzed Radical Relay Assembly of Aliphatic Keto-nitriles
preprintsubmitted on 29.09.2020, 11:59 and posted on 30.09.2020, 07:27 by Lei Chen, Shiyi Jin, Jian Gao, Tongtong Liu, Yuebo Shao, Jie Feng, Kangyi Wang, Tao Lu, Ding Du
An N-heterocyclic carbene and magnesium co-catalyzed three-component alkylacylation of alkenes with cycloketone oxime esters and aldehydes was presented. This method displayed good scope generality, providing a transition metal and photo-redox free pathway to access various multi-functionalized aliphatic keto-nitrile structures under mild reaction conditions. Moreover, this strategy is supposed to follow a radical relay mechanism via a single electron transfer (SET) event of Mg/oxime ester/Breslow intermediate ternary electron donating acceptor (EDA) complex.