ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Multiple C-H Activation-Densely Functionalized Arenes.pdf (10.19 MB)

Multiple C–H Activation Enabled Modular Construction of Densely Functionalized Sulfur-Contained Arenes

preprint
submitted on 20.01.2021, 09:06 and posted on 21.01.2021, 05:25 by Wensen Ouyang, Jianhang Rao, Jie Wang, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li

Modular construction of multiple functionalized arenes from abundant feedstocks, stands as an unremitting pursue goal in synthetic chemistry, which would accelerate the discovery of new drugs an advanced materials. Herein, by using multiple C-H activation strategy, through judicious choice of versatile imidate ester as the key directing group, expedi-ent delivery of molecular libraries of densely functionalized sulfur-contained arenes. Further synthetic application was demonstrated by multiple C-H modification of fused arenes and pharmaceuticals such as Ibuprofen, and concise con-struction of biologically active molecules, Madam dihydrochloride and Bipenamol, was also achieved.


Funding

National Natural Science Foundation of China (No. 22071034, 21602032)

Science and Technology Planning of Guangdong Province (No. 2019A050510042)

History

Email Address of Submitting Author

xwli@gdut.edu.cn

Institution

Guangdong University of Technology

Country

China

ORCID For Submitting Author

0000-0002-4014-6712

Declaration of Conflict of Interest

There are no conflicts to declare

Exports