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Seema_Paper_ORF10.pdf (572.23 kB)
ORF10: Molecular Insights into the Contagious Nature of Pandemic Novel Coronavirus 2019-nCoV
Preprints are manuscripts made publicly available before they have been submitted for formal peer review and publication. They might contain new research findings or data. Preprints can be a draft or final version of an author's research but must not have been accepted for publication at the time of submission.
This article stems from the author's observations that ORF10, a protein with no sequence and structural conservation, provides with a high number of potentially immunogenic, promiscuous epitopes. With high degree of epitope conservation across CTL and HTL epitopes of ORF10, its existence in the 2019-nCoV genome is largely seen as particularly contributing to the highly contagious nature of this virus.