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Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans.pdf (1.57 MB)
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Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans

preprint
submitted on 07.02.2020 and posted on 07.02.2020 by Miriam Velasquez, Efwita Astria, Sarah Winkler, Weibin Liang, Heinz Amenitsch, Arpita Poddar, Ravi Shukla, Glenn Prestwich, John Paderi, Christian Doonan, paolo falcaro
In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The GAG@MOF biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.

Funding

Horizon 2020 FETOPEN-1-2016-2017

History

Email Address of Submitting Author

miriam.jvh@gmail.com

Institution

Graz University of Technology (TU GRAZ)

Country

Austria

ORCID For Submitting Author

0000-0002-1338-4459

Declaration of Conflict of Interest

No conflict of interest to declare

Version Notes

The corresponding authors are: Prof. Christian Doonan and Prof. Paolo Falcaro

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