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Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans.pdf (1.57 MB)
Modulation of Metal-Azolate Frameworks for the Tunable Release of Encapsulated Glycosaminoglycans
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In this work, selected GAG-based biotherapeutics, including one proteoglycan, were successfully encapsulated with high efficiency in three different pH-responsive metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The GAG@MOF biocomposites obtained present significant differences in terms of crystallinity, particle size, and spatial distribution of the cargo, which enables to modulate their performance as drug delivery systems.