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Hilton ChemRixV 2019.pdf (526.35 kB)

Modular 3D Printed Compressed Air Driven Continuous-Flow Systems for Chemical Synthesis

preprint
submitted on 28.02.2019 and posted on 28.02.2019 by Matthew Penny,, Zenobia Rao, Bruno Peniche, Stephen Hilton
In this present study, we describe the development of a low-cost, small-footprint and modular 3D printed continuous-flow system that readily attaches to existing stirrer hotplates. Flow-rates are controlled by compressed air that is typically present in all fume hoods, making it suitable for use by synthetic chemists. The length of the flow-path and reaction residence time is regulated by control of the air-flow and pressure and by addition of one or more 3D printed polypropylene (PP) circular disk reactors that were designed to fit a DrySyn Multi-E base which is found in most synthetic laboratories. The ease of use of the system, the facile control of flow-rates and the solvent resistance of the PP reactors was demonstrated in a range of SNAr reactions to produce substituted ether derivatives highlighting the utility and modularity of the system.

Funding

None

History

Email Address of Submitting Author

s.hilton@ucl.ac.uk

Institution

UCL School of Pharmacy

Country

UK

ORCID For Submitting Author

0000-0001-8782-4499

Declaration of Conflict of Interest

None

Version Notes

This is version 1.0

Exports