Missing Reactivity of Trimethylsilyl Reagents: Dehalogenative Activation Enabling One-Pot Generation of Aryne from 2-Iodophenol

03 April 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Herein we present a missing reactivity of trimethylsilyl reagents; dehalogenative activation, which involves abstracting a halogen atom and anionically activating the substrate similar to the halogen-metal exchange reaction in classical carbanion species. This missing reactivity allowed for the one-pot generation of aryne from 2-iodophenol.

Keywords

exchanges
aryne reaction classes
aryne precursors

Supplementary materials

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Description
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Title
190314-silicate-SI
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