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Missing Reactivity of Trimethylsilyl Reagents: Dehalogenative Activation Enabling One-Pot Generation of Aryne from 2-Iodophenol
preprintsubmitted on 02.04.2019, 02:27 and posted on 03.04.2019, 15:51 by Koichiro Mikami, Takaaki Hirano, Hanamura Hitoshi
Herein we present a missing reactivity of trimethylsilyl reagents; dehalogenative activation, which involves abstracting a halogen atom and anionically activating the substrate similar to the halogen-metal exchange reaction in classical carbanion species. This missing reactivity allowed for the one-pot generation of aryne from 2-iodophenol.