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Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants

preprint
submitted on 05.06.2020 and posted on 08.06.2020 by Laura Ruiz-Cantu, Gustavo Trindade, Vincenzo Taresco, Zuoxin Zhou, Laurence Burroughs, Elizabeth Clark, Felicity R. A. J. Rose, Morgan Alexander, Christopher Tuck, Richard Hague, Clive Roberts, Derek Irvine, Ricky Wildman

Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. In this study, we show that ink jet 3D printing of polymer blends gives rise to controllable phase separation that can be used to tailor the release of drugs. We predicted phase separation using high throughput screening combined with a model based on the Flory-Huggins interaction parameter, and were able to show that drug release from 3D printed structures can be predicted from observations based on single drops of mixtures. This new understanding gives us hierarchical compositional control, from droplet to device, allowing release to be ‘dialed up’ without any manipulation of geometry. This is an important advance for implants that need to be delivered by cannula, where the shape is highly constrained and thus the usual geometrical freedoms associated with 3D printing cannot be exploited, bringing a hitherto unseen level of understanding to emergent material properties of 3D printing.

Funding

Formulation for 3D printing: Creating a plug and play platform for a disruptive UK industry

Engineering and Physical Sciences Research Council

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Enabling Next Generation Additive Manufacturing

Engineering and Physical Sciences Research Council

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Next Generation Biomaterials Discovery

Engineering and Physical Sciences Research Council

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3D OrbiSIMS: Label free chemical imaging of materials, cells and tissues

Engineering and Physical Sciences Research Council

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History

Email Address of Submitting Author

ricky.wildman@nottingham.ac.uk

Institution

University of Nottingham

Country

United Kingdom

ORCID For Submitting Author

0000-0003-2329-8471

Declaration of Conflict of Interest

No conflict of interest.

Version Notes

Version v1.0 Manuscript and Supplementary Info

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