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Microbial Cleavage of C‒F Bonds in Per- and Polyfluoroalkyl Substances via Dehalorespiration

preprint
revised on 25.11.2019 and posted on 29.11.2019 by Yaochun Yu, Kunyang Zhang, Zhong Li, Changxu Ren, Jinyong Liu, Yujie Men
Regarding the emerging concerns of the widely occurred and environmentally persistent per- and polyfluoroalkyl substances (PFASs), one intriguing and unsolved scientific question for environmental microbiologists, chemists, and engineers is that whether microbial reductive defluorination of perfluorinated compounds exist in nature. Due to the strong dissociation energy of carbon‒fluorine (C‒F) bonds in PFASs, no convincing evidence for biological cleavage of C‒F bonds from > C2 perfluorinated structures has ever been reported. We for the first time show C‒F bond cleavage via reductive defluorination by an organohalide-respiring microbial community for two PFASs, perfluoro(4-methylpent-2-enoic acid) and 4,5,5,5-tetrafluoro-4-(trifluoromethyl)-2-pentenoic acid. Comprehensive biotransformation pathways are further elucidated. This study brings valuable fundamental knowledge of microbial dehalorespiration, which opens avenues for the future exploration of PFAS environmental fate and bioremediation strategies.

Funding

NSF-CHE-1709286

NSF-CHE-1709719

History

Email Address of Submitting Author

ymen@engr.ucr.edu

Institution

University of California, Riverside

Country

United States

ORCID For Submitting Author

0000-0001-9811-3828

Declaration of Conflict of Interest

No conflict of interest

Version Notes

preprint version 4

Exports