These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
electrochemical bromocyclization of indoles - ChemRXIV.pdf (965.14 kB)

Electrochemical Synthesis of 3a-Bromofuranoindolines and 3a-Bromopyrroloindolines Mediated by MgBr2

revised on 26.11.2019, 15:19 and posted on 06.12.2019, 07:48 by Ju Wu, Hussein Abou Hamdan, Régis Guillot, Cyrille Kouklovsky, Guillaume Vincent

We report an efficient and environmentally friendly electrochemical approach to perform the bromo cyclization of tryptophol, tryptamine and tryptophan derivatives. The 3a-bromofuranoindolines and 3a-bromopyrroloindolines obtained are of interest in the total synthesis of natural products. This dearomative procedure relies on the generation of an electrophilic bromine reagent by the electrochemical oxidation of MgBr2. No organic byproducts are generated with this protocol which avoids the use of an additional electrolyte.


Chinese Scholarship Council (CSC, PhD fellowship to Ju Wu)

Agence Nationale de la Recherche (ANR-17-CE07-0050; “ArDCo”),


Email Address of Submitting Author


Université Paris Sud



ORCID For Submitting Author


Declaration of Conflict of Interest

no conflict of interest