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Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

preprint
submitted on 05.05.2020 and posted on 06.05.2020 by Barbara Souza, Jin-Chong Tan
We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from in situ manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

Funding

Minas Gerais Research Foundation (FAPEMIG CNPJ n21.949.888/0001-83)

ERC Consolidator Grant under the grant agreement 771575 (PROMOFS)

History

Email Address of Submitting Author

jin-chong.tan@eng.ox.ac.uk

Institution

University of Oxford

Country

United Kingdom

ORCID For Submitting Author

https://orcid.org/0000-0002-5770-408X

Declaration of Conflict of Interest

NA

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