ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Mechanistic Approaches for Modifying the Coordination Sphere of Metal–Amyloid-β Complexes: Covalent Adduct Formation and Oxidation

preprint
submitted on 03.05.2019 and posted on 06.05.2019 by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Junghyun Chae, Mi Hee Lim

We report, for the first time, a novel mechanistic tactic to directly modify the coordination sphere of Cu(II)–Aβ complexes in a metal binding residue-specific manner, which can prevent Cu(II) binding to Aβ, modulate the aggregation of Cu(II)–Aβ, and generate chemically transformed Aβ with less cytotoxicity, to the best of our knowledge.

Funding

National Research Foundation of Korea (NRF) grant funded by the Korean government

Korea Advanced Institute of Science and Technology (KAIST)

History

Email Address of Submitting Author

miheelim@kaist.ac.kr

Institution

Korea Advanced Institute of Science and Technology (KAIST)

Country

Republic of Korea

ORCID For Submitting Author

0000-0003-3377-4996

Declaration of Conflict of Interest

The authors declare no competing financial interest.

Exports