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Mechanistic Approaches for Modifying the Coordination Sphere of Metal–Amyloid-β Complexes: Covalent Adduct Formation and Oxidation

submitted on 03.05.2019, 09:42 and posted on 06.05.2019, 16:54 by Jiyeon Han, Hyuck Jin Lee, Kyu Yeon Kim, Junghyun Chae, Mi Hee Lim

We report, for the first time, a novel mechanistic tactic to directly modify the coordination sphere of Cu(II)–Aβ complexes in a metal binding residue-specific manner, which can prevent Cu(II) binding to Aβ, modulate the aggregation of Cu(II)–Aβ, and generate chemically transformed Aβ with less cytotoxicity, to the best of our knowledge.


National Research Foundation of Korea (NRF) grant funded by the Korean government

Korea Advanced Institute of Science and Technology (KAIST)


Email Address of Submitting Author


Korea Advanced Institute of Science and Technology (KAIST)


Republic of Korea

ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no competing financial interest.