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submitted on 18.06.2020 and posted on 19.06.2020by Wenhan XU, Zhijun Zhang, Miaomiao Kang, Heng Guo, Youmei Li, Haifei Wen, Michelle Mei Suet Lee, Zhaoyu Wang, Jacky W. Y. Lam, Ryan Tsz Kin Kwok, Kai Li, Lei Xi, Sijie Chen, Dong Wang, Ben Zhong Tang
A single-component multi-modal
theranostic platform taking advantage of multiple imaging and therapy
techniques may offer improved diagnostic monitoring capabilities and
therapeutic efficacies. In this study, through structural tuning, a novel
theranostic agent TSSAM with aggregation-induced emission (AIE)
characteristics, bright second near-infrared (NIR-II) emission, high reactive
oxygen species (ROS) generation capability and excellent photothermal
conversion efficiency (40.1%) was developed. TSSAM makes the best use of its
excited state energy and keeps perfect equilibrium between radiative and
non-radiative transition to satisfy the needs of both NIR-II fluorescence
imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal
imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic
therapy. Further experiments validated the superior imaging quality and
tumoricidal activity of TSSAM, in which tumor tissues were completely
eradicated and tumor metastasis was effectively inhibited by merely single
injection and one-time laser irradiation. This research has therefore presented
a smart multifunctional material holding great promise in both basic research
and clinical practice.