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Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on NIR-II AIEgens

preprint
submitted on 18.06.2020 and posted on 19.06.2020 by Wenhan XU, Zhijun Zhang, Miaomiao Kang, Heng Guo, Youmei Li, Haifei Wen, Michelle Mei Suet Lee, Zhaoyu Wang, Jacky W. Y. Lam, Ryan Tsz Kin Kwok, Kai Li, Lei Xi, Sijie Chen, Dong Wang, Ben Zhong Tang
A single-component multi-modal theranostic platform taking advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities and therapeutic efficacies. In this study, through structural tuning, a novel theranostic agent TSSAM with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability and excellent photothermal conversion efficiency (40.1%) was developed. TSSAM makes the best use of its excited state energy and keeps perfect equilibrium between radiative and non-radiative transition to satisfy the needs of both NIR-II fluorescence imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic therapy. Further experiments validated the superior imaging quality and tumoricidal activity of TSSAM, in which tumor tissues were completely eradicated and tumor metastasis was effectively inhibited by merely single injection and one-time laser irradiation. This research has therefore presented a smart multifunctional material holding great promise in both basic research and clinical practice.

History

Email Address of Submitting Author

wxuax@connect.ust.hk

Institution

the Hong Kong University of Science and Technology

Country

China

ORCID For Submitting Author

0000-0002-7572-616X

Declaration of Conflict of Interest

There is no conflict of interest.

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