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submitted on 28.01.2020 and posted on 29.01.2020by guillaume force, david leboeuf
Macrolactones constitute a privileged class of natural
and synthetic products with a broad range of applications in the fine chemicals
and pharmaceutical industry. Despite all the
progresses made towards their synthesis, notably from seco-acids, a macrolactonization promoter system that is effective,
selective, flexible, readily available, and, insofar as possible, compatible
with manifold functional
groups is still lacking. Herein, we describe an alternative strategy
relying on a speculated supramolecular template to enable a convenient access
to macrolactones, macrodiolides and esters with a versatility that had not been
reached with classic methods.