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Macrolactonization Driven by Supramolecular Interactions
preprintsubmitted on 28.01.2020, 10:34 and posted on 29.01.2020, 05:05 by guillaume force, david leboeuf
Macrolactones constitute a privileged class of natural and synthetic products with a broad range of applications in the fine chemicals and pharmaceutical industry. Despite all the progresses made towards their synthesis, notably from seco-acids, a macrolactonization promoter system that is effective, selective, flexible, readily available, and, insofar as possible, compatible with manifold functional groups is still lacking. Herein, we describe an alternative strategy relying on a speculated supramolecular template to enable a convenient access to macrolactones, macrodiolides and esters with a versatility that had not been reached with classic methods.