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Light Induces Opening of Vascular Barrier for Precise Nanoparticle Delivery.pdf (1.19 MB)

Light Induces Opening of Vascular Barrier for Precise Nanoparticle Delivery

preprint
submitted on 20.07.2020 and posted on 21.07.2020 by Weizhi Qi, Tingting Li, Chen Zhang, Fei Liu, Jun Wang, Dandan Chen, Xiaofeng Fang, Changfeng Wu, Kai LI, Lei Xi
The endothelial barrier plays an essential role in health and disease by protecting organs from toxins while allowing nutrients to access the circulation. However, it is the major obstacle that limits the delivery of therapeutic drugs to the diseased tissue. Here, for the first time we show that near-infrared (NIR) laser pulses can transiently open the vascular barrier via photoacoustic force, enabling selective and substantial accumulation of nanoparticles inside specific tissues. The nanoparticle delivery in tumors by 10-minute laser scanning is ~6 times higher than that of the enhanced permeability and retention (EPR) effect in 24 hours under current experimental conditions. We further show substantial accumulation of nanoparticles in the mouse brain with intact skull through light-controlled opening of the blood-brain barrier (BBB). This approach opens a new door for tissue-specific delivery of nanomaterials with an unprecedented level of efficiency and precision.

Funding

Wearable photoacoustic brain imaging

National Natural Science Foundation of China

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Preparation of near-infrared two-region multi-modal nanoprobe based on aggregation-induced luminescent material and its application in tumor diagnosis and treatment

National Natural Science Foundation of China

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Dual-mode imaging system for early diagnosis of finger osteoarthritis

National Natural Science Foundation of China

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Polymer quantum dot implanted glucose sensor and related micro-optical systems

National Natural Science Foundation of China

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Guangdong Innovative and Entrepreneurial Research Team Program

the Science and Technology Innovation Committee of Shenzhen Municipality

History

Email Address of Submitting Author

11951001@mail.sustech.edu.cn

Institution

Southern University of Science and Technology

Country

China

ORCID For Submitting Author

0000-0001-6592-4982

Declaration of Conflict of Interest

There is no conflict of interest.

Version Notes

Version 1. 20 Jul, 2020.

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