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Vercruysse_Chem Preprint_light or dark colored DOPA melanins_draft.pdf (666.31 kB)

Light- or Dark-Colored, L-DOPA-Based Melanins

preprint
submitted on 25.06.2018 and posted on 26.06.2018 by Koen Vercruysse, Margaret M. Whalen

This report is a continuation of previous research on the H2O2-mediated synthesis of melanin-like pigments. We synthesized and characterized L-DOPA-based pigments using air- or H2O2-mediated oxidation. We compared their physic-chemical properties and evaluated their capacity to affect the interleukin release from immune cells. The use of higher concentrations of H2O2 resulted in melanin-like materials with a distinct chemical signature in their FT-IR spectra and a lighter color. All pigments enhanced the interleukin release from immune cells. The possibility that lighter-colored melanins can be generated is discussed in the context of the importance of melanin-based pigmentation in human physiology.

Funding

U54CA163066

History

Email Address of Submitting Author

kvercruysse@tnstate.edu

Email Address(es) for Other Author(s)

mwhalen@tnstate.edu

Institution

Tennessee State University

Country

USA

ORCID For Submitting Author

0000-0003-2420-1985

Declaration of Conflict of Interest

None

Version Notes

First version of this manuscript and continuation of earlier work.

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