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Light-Powered, yet Chemically Fueled, Dissipative DNA Systems with Transient Lifecycles

submitted on 20.11.2019, 11:50 and posted on 28.11.2019, 06:16 by Jie Deng, Dominik Bezold, Henning J. Jessen, Andreas Walther

Fuel-driven dissipative self-assemblies are gaining ground for creating life-like, active and adaptive materials with autonomous behavior. However, up to now there is a lack for simple external control mechanisms of the transient behavior of the steady-state properties, at best using high spatiotemporal resolution. Here, we introduce the first examples of an externally controlled, chemically fueled transient self-assembly system that is ultimately powered using different colors of light. We demonstrate this concept for the programming of the transient lifecycle behaviors of ATP-dissipating, enzymatically controlled, dynamic covalent DNA polymerizations using controlled photolysis of properly designed caged ATP derivatives. Multiple uncaging, as well as wavelength-orthogonal activation are achieved by storing caged fuels as latent energy sources inside the system. We anticipate that this approach can be generalize to other ATP-dissipating self-assemblies and other chemical fuels to achieve versatile spatiotemporal control.


European Research Council Starting Grant 677960


Email Address of Submitting Author


University of Freiburg



ORCID For Submitting Author


Declaration of Conflict of Interest