ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

preprint
revised on 14.10.2019 and posted on 16.10.2019 by Angelo Frei, Maite Amado, Matthew Cooper, Mark A. T. Blaskovich
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal-complexes offer access to potential alternative modes of action and have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug resistant bacteria. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

Funding

Swiss National Science Foundation, P2ZHP2_177997

APP1059354

WT1104797/Z/14/Z

History

Email Address of Submitting Author

angelo.frei.ch@gmail.com

Institution

Institute for Molecular Bioscience, The University of Queensland

Country

Australia

ORCID For Submitting Author

0000-0001-6169-2491

Declaration of Conflict of Interest

There are no conflicts to declare.

Version Notes

Version 2_submitted

Exports