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Ligand Enabled Nickel-Catalyzed Asymmetric Hydroarylation of Styrenes and 1,3-Dienes with Arylboronic Acids
preprintsubmitted on 25.02.2019, 07:53 and posted on 25.02.2019, 17:51 by XINYANG Lv, CHAO FAN, LIJUN XIAO, JIANHUA XIE, QILIN ZHOU
A chiral spiro aminophosphine ligand enabled nickel-catalyzed asymmetric hydroarylation of styrenes and 1,3-dienes with arylboronic acids. The reaction was promoted by a Ni–H species generated from protonation of Ni(0) with alcohol. This reaction uses only catalytic amount reagents and provided an efficient, straightforward and mild method for preparing enantioenriched 1,1-diarylalkanes, which are important motifs for the synthesis of many biologically active molecules.