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Ligand-Accelerated Non-Directed C–H Cyanation of Arenes

preprint
submitted on 10.09.2018 and posted on 11.09.2018 by Luoyan Liu, Kap-Sun Yeung, jin-quan yu

We herein report the first example of a 2-pyridone accelerated non-directed C−H cyanation with an arene as the limiting reagent. This protocol is compatible with a broad scope of arenes, including advanced intermediates, drug molecules, and natural products. A kinetic isotope experiment (kH/kD = 4.40) indicates that the C–H bond cleavage is the rate-limiting step. Also, the reaction is readily scalable, further showcasing the synthetic utility of this method.

Funding

NIGMS, 2R01GM084019

History

Email Address of Submitting Author

yu200@scripps.edu

Institution

The Scripps Research Institute

Country

USA

ORCID For Submitting Author

0000-0003-3560-5774

Declaration of Conflict of Interest

no conflict of interest

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Read the published paper

in Chemistry - A European Journal

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