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Kinetic Analysis of the Hydrolysis of Pentose-1-Phosphates Through Apparent Nucleoside Phosphorolysis Equilibrium Shifts

preprint
submitted on 14.10.2020 and posted on 15.10.2020 by Felix Kaspar, Peter Neubauer, Anke Kurreck
Ask what an equilibrium can do for you:
Hydrolysis of pentose-1-phosphates leads to an apparent increase of the equilibrium conversion in nucleoside phosphorolysis reactions. This information can be leveraged via equilibrium thermodynamics to determine the hydrolysis kinetics of in situ generated sugar phosphates, which are known to be elusive and difficult to quantify.

History

Email Address of Submitting Author

felix.kaspar@web.de

Institution

Technische Universität Berlin

Country

Germany

ORCID For Submitting Author

0000-0001-6391-043X

Declaration of Conflict of Interest

A. K. is CEO of the biotech company BioNukleo GmbH. F. K. is a scientist at BioNukleo GmbH and P. N. is a member of the advisory board. These affiliations constitute no conflict of interest with the results presented and discussed in this report.

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