ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
0/0

Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? An Answer from All-Atoms Simulations

preprint
revised on 21.04.2020 and posted on 22.04.2020 by Angelo Spinello, Andrea Saltalamacchia, Alessandra Magistrato

The latest outbreak of a new pathogenic coronavirus (SARS-CoV-2) is provoking a global health, economic and societal crisis. All-atom simulations enabled us to uncover the key molecular traits underlying the high affinity of SARS-CoV-2 spike glycoprotein towards its human receptor, providing a rationale to its high infectivity. Harnessing this knowledge can boost developing effective medical countermeasures to fight the current global pandemic.

History

Email Address of Submitting Author

alessandra.magistrato@sissa.it

Institution

CNR-IOM c/o SISSA

Country

Italy

ORCID For Submitting Author

https://orcid.org/0000-0002-2003-1985

Declaration of Conflict of Interest

No conflict of interest

Exports