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Iodolopyrazolium Salts – Synthesis, Derivatizations and Applications
preprintsubmitted on 31.07.2020, 13:32 and posted on 03.08.2020, 06:40 by Andreas Boelke, Thomas Kuczmera, Lucien Caspers, Enno Lork, Boris Nachtsheim
A fast and reliable synthesis of pyrazole-substituted iodolium triflates is described. Their versatile application as useful synthetic intermediates for straight-forward modifications of pharmaceuticals is demonstrated using Celecoxib as model substrate. Finally, their application as potent halogen-bond donors in a Ritter-type reaction is shown.