ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
3 files

Iodolopyrazolium Salts – Synthesis, Derivatizations and Applications

preprint
submitted on 31.07.2020, 13:32 and posted on 03.08.2020, 06:40 by Andreas Boelke, Thomas Kuczmera, Lucien Caspers, Enno Lork, Boris Nachtsheim
A fast and reliable synthesis of pyrazole-substituted iodolium triflates is described. Their versatile application as useful synthetic intermediates for straight-forward modifications of pharmaceuticals is demonstrated using Celecoxib as model substrate. Finally, their application as potent halogen-bond donors in a Ritter-type reaction is shown.

Funding

Fonds der Chemischen Industrie

History

Email Address of Submitting Author

nachtsheim@uni-bremen.de

Institution

University of Bremen

Country

Germany

ORCID For Submitting Author

0000-0002-3759-2770

Declaration of Conflict of Interest

no conflict of interest

Version Notes

first draft

Exports

Logo branding

Exports